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Medchemexpress LLC VU 0357121 | 433967-28-3 | C17H17F2NO2 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY15393100MG

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VU 0357121 is a positive and highly selective mGlu5R allosteric modulator (PAM) with an EC50 of 33 nM. It is inactive or very weakly antagonizing at other mGlu receptor subtypes. It enhances glutamate sensitivity of mGlu5, likely due to an interaction at a site on the receptor distinct from the MPEP binding site, and does not possess mGlu5 NAM activity. It is for research use only.

  • Enhances glutamate sensitivity of mGlu5
  • Does not bind at the MPEP allosteric site of mGlu5
  • A809V/rmGlu5 mutation inhibited the ability to shift the glutamate concentration response curve
  • Response is not altered by the F585I/rmGlu5 mutation

Catalog No. 50-003-76523


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