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Apexbio Technology LLC VU 0361737 1161205-04-4 100mg
Supplier: Apexbio Technology LLC B1630100
VU 0361737 (CAS 1161205-04-4) is a selective brain-penetrant positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4) It demonstrates high selectivity for mGluR4 over other mGluR subtypes with EC50 values of 240 nM for human and 110 nM for rat mGluR4 and shows minimal to no activity at mGluR1 mGluR2 mGluR3 mGluR6 and mGluR7 while exhibiting weak activity at mGluR5 and mGluR8 VU 0361737 crosses the blood-brain barrier and achieves significant brain exposure (brain plasma ratio of 4 1) with a short half-life (T1/2 20 min) following administration in rats This compound is utilized in studies exploring the modulation of basal ganglia neurotransmission and the pathophysiology of Parkinson s disease
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