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Medchemexpress LLC VU0357017 hydrochloride | 1135242-13-5 | 98.6% | 369.89 | 100 MG
Supplier: Medchemexpress LLC HY19752A100MG
VU0357017 hydrochloride is a potent, selective, and brain-penetrant allosteric agonist of the M1 muscarinic acetylcholine receptor, with an EC50 of 477 nM. It demonstrates high selectivity for M1, exhibiting no activity at M2-M5 even at concentrations up to 30 μM. This compound is suitable for research related to Alzheimer's disease and schizophrenia.
- Potent, selective and brain-penetrant allosteric agonist of M1 muscarinic acetylcholine receptor.
- Exhibits an EC50 of 477 nM for M1.
- Highly selective for M1, with no activity at M2-M5 up to 30 μM.
- Can be used for the research of Alzheimer's disease and schizophrenia.
- Induces calcium release and ERK phosphorylation in a concentration-dependent manner in CHO cells.
- Reverses scopolamine-induced disruption of the contextual fear conditioning response.
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