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Medchemexpress LLC VU0357017 hydrochloride | 1135242-13-5 | 98.6% | 369.89 | 50 MG
Supplier: Medchemexpress LLC HY19752A50MG
VU0357017 hydrochloride is a potent, selective, and brain-penetrant allosteric agonist of the M1 muscarinic acetylcholine receptor, exhibiting an EC50 of 477 nM. This compound demonstrates high selectivity for M1, showing no activity at M2-M5 receptors at concentrations up to 30 μM. It is being investigated for its potential use in the research of Alzheimer's disease and schizophrenia.
- Potent and selective allosteric agonist of M1 muscarinic acetylcholine receptor.
- Brain-penetrant.
- Highly selective for M1, with no activity at M2-M5 receptors at tested concentrations.
- Induces calcium release and ERK phosphorylation in CHO cells.
- Reverses scopolamine-induced cognitive deficits in animal models.
- Potential for research in Alzheimer's disease and schizophrenia.
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