Cayman Chemical VU0360172hydrochlorIde 10mg

Supplier:  Cayman Chemical 2207410 MG

A positive allosteric modulator of mGluR5 (Ki = 195 nM); selective for mGluR5 over mGluR1, mGluR3, and mGluR4 at 10 µM; prevents TNF-α and NO production by IFN-γ- or LPS-stimulated BV-2 and primary microglial cells at 20 and 50 µM; reduces expression of iNOS and increases expression of Ym1 and arginase 1 in LPS-stimulated BV-2 cells at 20 µM; reduces the size of cortical lesions, prevents hippocampal neurodegeneration, and improves sensorimotor deficits in the beam walk test in a mouse model of traumatic brain injury (TBI)

Catalog No. 50-298-7277