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Apexbio Technology LLC VX-222 (VCH-222, Lomibuvir) 1026785-59-0 100mg
Supplier: Apexbio Technology LLC A4032100
VX-222 (VCH-222 Lomibuvir) is a non-nucleoside inhibitor of hepatitis C virus (HCV) RNA polymerase functioning through direct interaction with the polymerase enzyme It targets the thumb II allosteric pocket of the HCV RNA-dependent RNA polymerase (NS5B) mediating inhibition specifically by interfering with primer-dependent RNA synthesis rather than de novo initiation The inhibitory mechanism is attributed to hydrophobic interactions between its 4-methylcyclohexyl moiety and residues L412 M423 and I482 within the polymerase domain VX-222 demonstrates variable inhibitory activities in biochemical assays exhibiting IC50 values ranging from 0 011 to greater than 5 M depending on RNA template conditions making it suitable for antiviral mechanism and viral replication studies
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