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Apexbio Technology LLC VX-680 (MK-0457,Tozasertib) 639089-54-6 250mg
Supplier: Apexbio Technology LLC A4111250
VX-680 (also known as MK-0457 or tozasertib CAS 639089-54-6) is a small-molecule inhibitor discovered via molecular screening characterized by its broad inhibitory activity against aurora kinases (pan-aurora inhibitor) In addition to targeting aurora kinases VX-680 also inhibits several other kinases including Src GSK3 Flt3 JAK2 and both wild-type and T315I mutant forms of BCR-Abl It exerts its effect by binding to the inactive conformation of non-aurora kinases resulting in suppression of kinase activation In cellular assays and xenograft models VX-680 has demonstrated significant anti-proliferative activity across diverse tumor types such as ovarian renal thyroid oral squamous cell carcinomas CML AML and multiple myeloma supporting its utility in cancer research
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