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Selleck Chemical LLC Tozasertib (VX-680, MK-0457) 10mM/1mL 639089-54-6
Supplier: Selleck Chemical LLC S104810MM/1ML
Tozasertib (VX-680, MK-0457) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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