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Apexbio Technology LLC VX-765 273404-37-8 100mg
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Supplier:  Apexbio Technology LLC A8238100

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VX-765 (CAS 273404-37-8) is an orally bioavailable prodrug of VRT-043198 a selective inhibitor targeting caspase-1 (also known as IL-1 converting enzyme ICE) Caspase-1 plays a pivotal role in processing pro-inflammatory cytokines specifically converting inactive precursors of IL-1 and IL-18 into bioactive forms VX-765 downstream metabolite VRT-043198 selectively reduces the secretion of IL-1 and IL-18 in stimulated human peripheral blood mononuclear cells without affecting release of other cytokines such as IL-6 or TNF- Preclinical studies demonstrate VX-765 activity in mouse models of arthritis dermatitis and HIV-associated CD4 T-cell death indicating utility in inflammatory and immunological research

Catalog No. 50-000-62189


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