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Medchemexpress LLC W1131 TFA 10mM | 2740522-79-4 | C₂₅H₂₀F₃NO₈ | 1 ML
Supplier: Medchemexpress LLC HY153190A10MM/1ML
W1131 TFA is a potent STAT3 inhibitor and ferroptosis inducer. It demonstrates anti-cancer properties by inhibiting tumor growth and alleviating chemoresistance in gastric cancer models. W1131 TFA regulates critical cellular processes including the cell cycle, DNA damage response, and oxidative phosphorylation, specifically impacting the IL6-JAK-STAT3 and ferroptosis pathways.
- Potent STAT3 inhibitor
- Induces ferroptosis
- Inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer
- Alleviates cancer cell chemoresistance to 5-FU
- Regulates cell cycle and DNA damage response
- Modulates oxidative phosphorylation
- Impacts IL6-JAK-STAT3 pathway
- Affects ferroptosis pathway
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