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Apexbio Technology LLC WAY 316606(Synonyms: WAY-316606, WAY316606, WAY 316606 sFRP-1 inhibitor, sFRP-1 inhibitor WAY 316606), 5mg, CAS: 915759-45-4.
Supplier: Apexbio Technology LLC A39325
WAY 316606 (CAS 915759-45-4) is a selective small molecule inhibitor targeting secreted frizzled-related protein 1 (sFRP-1) an endogenous antagonist of Wnt signaling WAY 316606 binds specifically to sFRP-1 (Kd 0 08 M) reducing its inhibitory effect and thus activating the canonical Wnt pathway In cell-based reporter assays using U2-OS osteosarcoma cells WAY 316606 dose-dependently promoted Wnt signaling with an EC50 of 0 65 M Ex vivo studies with neonatal murine calvarial tissue further demonstrated that WAY 316606 enhances osteoblast activity and bone formation This compound serves as a research tool for investigating Wnt-associated bone metabolism and therapeutic strategies for metabolic bone disorders
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