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Apexbio Technology LLC WAY-600 1062159-35-6 200mg
Supplier: Apexbio Technology LLC B1641200
WAY-600 is an ATP-competitive inhibitor targeting mammalian target of rapamycin (mTOR) specifically inhibiting the phosphorylation activity mediated by mTOR complexes It suppresses mTORC1 signaling via inhibition of phosphorylation of ribosomal S6 kinase (S6K) at Thr389 and attenuates mTORC2 signaling by inhibiting phosphorylation of protein kinase B (AKT) at Ser473 Importantly WAY-600 does not interfere with AKT phosphorylation at Thr308 The compound demonstrates marked selectivity for mTOR over phosphatidylinositol 3-kinase (PI3K) isoforms displaying greater than 100-fold selectivity against PI3K and over 500-fold selectivity against PI3K WAY-600 represents a valuable tool for investigating mTOR-dependent signaling pathways metabolism regulation cellular proliferation autophagy and related oncological and metabolic research areas
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