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Enzo Life Sciences Withaferin A (10mg). CAS: 5119-48-2
Supplier: Enzo Life Sciences BMLCT1040010
Cell permeable and potent angiogenesis inhibitor from the family of withanolides. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC50=12nM) and in vivo. Exhibits antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits NF-κB activation by preventing the TNF-induced activation of IκB kinase β (IKKβ). Elicits IKKß hyperphosphorylation concomitant with inhibition of its kinase activity. Affects AP1 transcription and induces cell death. Alters cytoskeletal architecture by covalently binding annexin II and stimulating its basal F-actin cross-linking activity which inhibits the migratory and invasive capability of endothelial cells. Targets the intermediate filament protein vimentin. Displays neuronal regenerative properties. Alternative name: 5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO (20 mg/ml), methanol (10 mg/ml) or 100% ethanol. Long Term Storage: -20°C.
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