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AdipoGen Withaferin A,Chemical. CAS: 5119-48-2
Supplier: AdipoGen AGCN20490M001
Withaferin A, AdipoGen Life Sciences. Chemical. CAS: 5119-48-2. Formula: C28H38O6. MW: 470.6. Isolated from Withania somnifera. Multifunctional anticancer compound. Amplifies the cellular antioxidant and/or detoxification system, suppresses inflammatory pathways, selectively inhibits tumor cell proliferation and induces apoptosis, suppresses tumor angiogenesis, blocks epithelial-to-mesenchymal transition (EMT), tumor invasion and metastasis, alters tumor cell metabolism, induces immunomodulation and downregulates cancer stem cells targets. Sensitizes resistant cancer cells to existing chemotherapeutic agents. Antioxidant. Induces cytoprotective enzymes (Nrf2-dependent as well), including SOD, HO-1 (heme oxygenase-1), catalase, glutathione peroxidise, glutathione s-transferase and NQO1. Anti-inflammatory agent. Inhibits COX-2 and iNOS expression (at protein and mRNA level) and PGE2 production. 5119-48-2
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