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Medchemexpress LLC Withaferin A | 5119-48-2 | 470.60 | 1 ML
SDP

Catalog No. 5000415246
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Withaferin A is a steroidal lactone isolated from Withania somnifera. It inhibits NF-kB activation and targets vimentin, exhibiting potent anti-inflammatory and anticancer activities. It also acts as an inhibitor of endothelial protein C receptor (EPCR) shedding.

  • Inhibits NF-κB activation.
  • Targets vimentin.
  • Potent anti-inflammatory activity.
  • Potent anticancer activity.
  • Inhibits endothelial protein C receptor (EPCR) shedding.
  • Shows potent angiogenesis inhibitory activity via vimentin in mice (2 mg/kg, i.p.).
  • Combined with cisplatin (CIS), regulates ALDH1 marker expression and downregulates securin in tumors from mice.
  • Reduces tumorigenic potential of ALDH1 positive cancer stem cells (CSCs) at 0.5, 1.5 μM, alone or in combination with cisplatin.

Catalog No. 50-004-15246 Supplier Medchemexpress LLC Supplier No. HYN206510MM/1ML
May include imposed supplier surcharges.
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Withaferin A is a steroidal lactone isolated from Withania somnifera. It inhibits NF-kB activation and targets vimentin, exhibiting potent anti-inflammatory and anticancer activities. It also acts as an inhibitor of endothelial protein C receptor (EPCR) shedding.

  • Inhibits NF-κB activation.
  • Targets vimentin.
  • Potent anti-inflammatory activity.
  • Potent anticancer activity.
  • Inhibits endothelial protein C receptor (EPCR) shedding.
  • Shows potent angiogenesis inhibitory activity via vimentin in mice (2 mg/kg, i.p.).
  • Combined with cisplatin (CIS), regulates ALDH1 marker expression and downregulates securin in tumors from mice.
  • Reduces tumorigenic potential of ALDH1 positive cancer stem cells (CSCs) at 0.5, 1.5 μM, alone or in combination with cisplatin.

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