Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000062411

Apexbio Technology LLC Wnt-C59 1243243-89-1 10mM (in 1mL DMSO)
SDP

Catalog No. 5000062411
Encompass_Preferred

Wnt-C59 (CAS 1243243-89-1) is a selective inhibitor of the Wnt signaling pathway targeting Porcupine (PORCN) an acyltransferase essential for Wnt protein secretion Exhibiting an IC50 of 74 pM Wnt-C59 blocks cellular secretion of Wnt ligands thus preventing downstream activation of Wnt-dependent transcriptional activity Studies using cell lines such as HT1080 HeLa and cholangiocarcinoma-derived CC-LP-1 SUN-1079 and CC-SW-1 have demonstrated diminished cell viability reduced proliferation and increased apoptosis upon Wnt-C59 treatment In WNT-driven tumor mouse models Wnt-C59 administration significantly inhibits tumor growth highlighting its utility for studying Wnt-mediated cancer pathogenesis and therapeutic intervention strategies

Catalog No. 50-000-62411 Supplier Apexbio Technology LLC Supplier No. A86855.1
May include imposed supplier surcharges.
Add to Cart
Add to Cart

missing translation for 'validMainframeMsg'

Wnt-C59 (CAS 1243243-89-1) is a selective inhibitor of the Wnt signaling pathway targeting Porcupine (PORCN) an acyltransferase essential for Wnt protein secretion Exhibiting an IC50 of 74 pM Wnt-C59 blocks cellular secretion of Wnt ligands thus preventing downstream activation of Wnt-dependent transcriptional activity Studies using cell lines such as HT1080 HeLa and cholangiocarcinoma-derived CC-LP-1 SUN-1079 and CC-SW-1 have demonstrated diminished cell viability reduced proliferation and increased apoptosis upon Wnt-C59 treatment In WNT-driven tumor mouse models Wnt-C59 administration significantly inhibits tumor growth highlighting its utility for studying Wnt-mediated cancer pathogenesis and therapeutic intervention strategies

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.