STEMCELL Technologies Wortmannin, Size: 10 mg

Supplier:  STEMCELL Technologies 73564

Inhibit phosphatidylinositol-3-kinases of class I, II, and III with Wortmannin. This fungal metabolite also inhibits polo-like kinases PLK1 and PLK3 (Liu et al. Chem Biol, 2005; Liu et al. J Biol Chem, 2007), and, at high concentrations, inhibits other kinases such as mammalian target of rapamycin (mTOR), DNA-dependent protein kinase catalytic subunit (DNA-PKcs), myosin light-chain kinase (MLCK), and mitogen-activated protein kinase (MAPK; Fruman et al. Annu Rev Biochem, 1998; Hartley et al. Cell, 1995; Brunn et al. EMBO J, 1996; Nakanishi et al. J Biol Chem, 1992). Wortmannin also exhibits cytotoxic activity on a number of human tumor cell lines in vitro, and anti-tumor activity in mouse xenografts of C3H mammary carcinoma and BxPC-3 pancreatic carcinoma cells (Schultz et al. Anticancer Res, 1995; Yuan et al. Chem Biol, 2007). Wortmannin is supplied as a crystalline solid with ≥ 98% purity; Molecular weight 428.4 g/mol; CAS number 19545-26-7. Visit STEMCELL.com for more information.

Catalog No. 50-197-6097