Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Ws-383 | 2247544-02-9 | MFCD32182557 | 99.9% | 498.46 | C18H21Cl2N9S2 | 10MG
Supplier: Medchemexpress LLC HY126075A10MG
WS-383 is a potent, selective, and reversible small-molecule inhibitor of the DCN1-UBC12 protein-protein interaction (IC50 = 11 nM). It inhibits Cul3/1 neddylation in cells, resulting in accumulation of cell-cycle regulators p21 and p27 and increased NRF2, and shows cellular activity in relevant cancer cell lines.
- Potent and selective inhibitor with low-nanomolar biochemical potency.
- Cellular inhibition of Cul3 neddylation at low micromolar concentrations.
- Induces accumulation of p21, p27, and NRF2 in treated cells.
- High-purity solid suitable for biochemical and cellular assays.
- Available as solid and as a DMSO solution for cell-based work.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?