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Medchemexpress LLC WWL113 | 947669-86-5 | 99.7% | 466.53 | 1 ML
Supplier: Medchemexpress LLC HY11014810MG
WWL113 is a selective and orally active Ces3 and Ces1f inhibitor, with IC50 values of 120 nM and 100 nM for Ces3 and Ces1f, respectively. It appears to show excellent selectivity for the 60-kDa serine hydrolase (or hydrolases).
- Inhibits mouse recombinant Ces1, Ces1c, and ABHD6 at 10 μM.
- Significantly increases UCP1 protein expression in brown adipocytes at 1 μM.
- Has a partial, statistically significant inhibitory effect on blocking the buildup of PGE2.
- Results in major improvement of multiple features of metabolic syndrome and ameliorated obesity-diabetes in mice with lowered levels of nonesterified free fatty acids (NEFAs), triglycerides (TGs), total cholesterol and fasted glucose as well as enhanced glucose tolerance (30 mg/kg, orally once a day).
- Ameliorates obesity-diabetes in mice.
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