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Medchemexpress LLC WYE-687 | 1062161-90-3 | C28H32N8O3 | 5 MG
Supplier: Medchemexpress LLC HY152715MG
WYE-687 is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM. It concurrently inhibits the activation of mTORC1 and mTORC2. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively.
- ATP-competitive mTOR inhibitor
- Inhibits activation of mTORC1 and mTORC2
- Inhibits PI3Kα and PI3Kγ
- Potently inhibits HL-60 cell survival
- Cytotoxic to U937, THP-1 and AML-193 AML cell lines
- Significantly inhibits U937 xenograft tumor growth in SCID mice
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