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Apexbio Technology LLC WZ811 55778-02-4 1g
SDP

Supplier:  Apexbio Technology LLC B14661000

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WZ811 (CAS 55778-02-4) is a small molecule antagonist targeting the CXC chemokine receptor 4 (CXCR4) Structurally composed of two aromatic amine groups WZ811 inhibits the binding of TN14003 to CXCR4 with an EC50 of 0 3 nM and disrupts stromal cell-derived factor 1 (SDF-1)-mediated CXCR4 signaling In cAMP assays WZ811 significantly attenuates SDF-1-induced cAMP responses and impedes SDF-1-driven Matrigel invasion (EC50 5 2 nM) Given CXCR4 s involvement in infection inflammation and various diseases WZ811 serves as a valuable tool for interrogating CXCR4-related biological processes and disease models and has been reported to display modest anti-HIV activity in cell cultures

Catalog No. 50-000-90455


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