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Medchemexpress LLC XE991 dihydrochloride | 122955-13-9 | 99.6% | 449.37 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY10857750MG

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XE991 dihydrochloride is a Kv7 (KCNQ) channel blocker that potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channels, and M-current.

  • Potently inhibits Kv7.1 (KCNQ1) channels with an IC50 of 0.75 μM.
  • Inhibits Kv7.2 (KCNQ2) channels with an IC50 of 0.71 μM.
  • Blocks Kv7.2 + Kv7.3 (KCNQ3) channels with an IC50 of 0.6 μM.
  • Inhibits M-current with an IC50 of 0.98 μM.
  • Enhances [3H]ACh release from rat brain slices with an EC50 of 490 nM.
  • Demonstrates good in vivo potency and duration of action.

Catalog No. 50-003-45270


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