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Medchemexpress LLC XE991 dihydrochloride | 122955-13-9 | 99.6% | 449.37 | 500 UG
SDP

Supplier:  Medchemexpress LLC HY10857710MM/1ML

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XE991 dihydrochloride is a Kv7 (KCNQ) channels blocker that potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively. It has an EC50 of 490 nM for enhancement of [3H]ACh release from rat brain slices, and shows good in vivo potency and duration of action.

  • Potent Kv7 (KCNQ) channels blocker.
  • Inhibits Kv7.1, Kv7.2, Kv7.2 + Kv7.3 channels, and M-current.
  • IC50s: 0.75 μM (Kv7.1), 0.71 μM (Kv7.2), 0.6 μM (Kv7.2 + Kv7.3), 0.98 μM (M-current).
  • EC50 of 490 nM for enhancing [3H]ACh release from rat brain slices.
  • Good in vivo potency and duration of action.

Catalog No. 50-003-45273


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