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Selleck Chemical LLCSupplier Diversity Partner Cabozantinib (BMS-907351) 50mg 849217-68-1 XL184  DFS Item

Manufacturer:  Selleck Chemical LLCSupplier Diversity Partner S111950MG

Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway.

Catalog No. 50-622-6



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