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Medchemexpress LLC XL-3158 | 3117797-77-7 | 99.55% | 690.61 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY17480250MG

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XL-3158 is a selective, cross-species Cyclic GMP-AMP synthase (cGAS) inhibitor. It has an IC50 of 11.1 μM for human cGAS and 2.19 μM for mouse cGAS. This compound simultaneously occupies allosteric and orthosteric sites, stabilizing the activation loop in a closed, inactive conformation, which attenuates cGAS-DNA interactions. XL-3158 inhibits cGAS by targeting phase separation, efficiently penetrating cells by inhibiting aggregate formation and reducing the local concentration of cGAS within cells. It is suitable for studying cGAS-dependent inflammatory diseases.

  • Selective and cross-species cGAS inhibitor.
  • Inhibits cGAS by targeting phase separation.
  • Efficiently penetrates cells by inhibiting aggregate formation.
  • Reduces local concentration of cGAS within cells.
  • Can be used for the study of cGAS-dependent inflammatory diseases.

Catalog No. 50-003-86848


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