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Medchemexpress LLC XL-3158 | 99.6% | 690.61 g/mol | C30H17F7N6O2S2 | 10 MG
Supplier: Medchemexpress LLC HY17480210MG
XL-3158 is a selective, cross-species inhibitor of cyclic GMP-AMP synthase (cGAS) for research applications. It binds both allosteric and orthosteric sites to stabilize the activation loop in an inactive conformation, reducing cGAS-DNA interactions and phase separation. The compound shows cellular activity with limited cytotoxicity at effective concentrations and is suitable for studies of cGAS-dependent inflammatory pathways.
- Selective cross-species inhibition of cGAS
- Dual-site binding stabilizes inactive activation loop
- Reduces cGAS-DNA interactions and phase separation
- Demonstrated cellular activity with low cytotoxicity
- High purity suitable for cell-based assays
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