Medchemexpress LLC XL177A | 2417089-74-6 | 99.6% | 861.47 | 50 MG

Supplier:  Medchemexpress LLC HY13879450MG

XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC50 of 0.34 nM, demonstrating cancer cell killing through a p53-dependent mechanism. It acts as a potent USP7 inhibitor and p53 stabilizer in vitro, effectively suppressing cancer cell growth. The compound selectively labels the catalytic cysteine, C223, of USP7 across the DUBome and human proteome.

• Highly potent and selective irreversible USP7 inhibitor (IC50 of 0.34 nM).
• Elicits cancer cell killing via a p53-dependent mechanism.
• Suppresses cancer cell growth predominantly through p53-dependent pathways.
• Labels USP7's catalytic cysteine (C223) with exquisite selectivity.
• Induces complete G1 arrest in MCF7 cells after 24 hours (at 1 μM).
• Promotes rapid degradation of HDM2, increasing p53 and p21 protein levels in MCF7 cells.

Catalog No. 50-003-49271