Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC XL335 629664-81-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B15285.1
XL335 (CAS 629664-81-9) is a selective orally bioavailable agonist of the farnesoid X receptor (FXR) displaying an EC50 of approximately 4 nM In Hep3B liver cancer cells XL335 activation of FXR reduces interleukin-6-induced C-reactive protein (CRP) expression at both mRNA and protein levels In vivo studies indicate that XL335 diminishes lipopolysaccharide (LPS)-stimulated inflammatory responses and fructose-induced hepatic inflammation by suppressing acute-phase proteins (e g SAP SAA3) and adipose differentiation-related protein (ADRP) Thus XL335 serves as a valuable tool for investigating FXR-mediated pathways involved in liver inflammation and metabolic disorders
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?