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Apexbio Technology LLC XMD8-92 1234480-50-2 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A39435.1
XMD8-92 (CAS 1234480-50-2) is a potent small-molecule inhibitor of mitogen-activated protein kinase 7 (MAPK7/BMK1) demonstrating a Kd of 80 nM and inhibiting EGF-induced BMK1 activation with an IC50 of 240 nM In cellular studies XMD8-92 suppresses proliferation and tumor xenograft growth of cancer cell lines linked to upregulation of tumor-suppressive miRNAs and downregulation of DCLK1 and several oncogenic targets In murine models it impedes the progression of lung and cervical cancer xenografts primarily by affecting cell cycle regulation and angiogenesis XMD8-92 remains under preclinical investigation for its potential in cancer research
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