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Medchemexpress LLC xStAx-VHLL TFA | 100.0% | 3231.89 | 5 MG
Supplier: Medchemexpress LLC HYP5819A5MG
xStAx-VHLL TFA is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. It inhibits the Wnt/β-catenin signaling pathway. xStAx-VHLL TFA can also inhibit the proliferation of colon cancer cells and demonstrates anti-tumor activity.
- Induces β-catenin degradation in a dose-dependent manner in colorectal cancer cells in vitro
- Inhibits cell proliferation in vitro
- Inhibits Wnt/β-catenin signaling in HEK293T cells in vitro
- Shows antitumor activity in a mouse intestinal tumor model in vivo
- Reduces tumor number and active β-catenin protein levels in APC min/+ mice in vivo
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