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Medchemexpress LLC XY028-133 PROTAC-based CDK4/6 degrader | 2229974-73-4 | 98.62% | 1 ML
Supplier: Medchemexpress LLC HY12918010MM/1ML
XY028-133 is a PROTAC-based CDK4/6 degrader exhibiting anti-tumor activity. It is composed of ligands for von Hippel-Lindau and CDK, and has been shown to significantly reduce protein levels of CDK4/6, Cyclin A, PLK1, and pRb in A375 cells at concentrations of 1 and 3 μM over 24 hours.
- PROTAC-based CDK4/6 degrader
- Exhibits anti-tumor activity
- Composed of ligands for von Hippel-Lindau and CDK
- Reduces protein levels of CDK4/6, Cyclin A, PLK1, and pRb
- Targets CDK4 and CDK6
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