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Cayman Chemical Xylometazoline (hydrochloride), Purity: ≥98%, CAS: 1218-35-5, 1 g
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Catalog No. 502939535
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An α-AR agonist; binds to α1A-, α1B-, α1D-, α2A-, α2B-, and α2C-ARs in a radioligand binding assay (IC50s = 0.08, 0.56, 0.45, 0.98, 1.8, and 0.22 μM, respectively); increases intracellular calcium levels in HEK293 cells transfected with human α2B-ARs (EC50 = 99 μM) but not other α-ARs; a 5-HT1 receptor agonist (Kis = 0.7 and 14 nM for the human 5-HT1D and 5-HT1B receptors, respectively); inhibits forskolin-induced cAMP production in CHO Pro 5 cells expressing human 5-HT1D and 5-HT1B receptors by 62 and 49%, respectively, at 1 μM; induces contraction of isolated dog nasal mucosal blood vessels at 0.25 μg/ml; reduces nasal patency in dogs when administered topically or intravenously

Catalog No. 50-293-9535 Supplier Cayman Chemical Supplier No. 277971 G
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An α-AR agonist; binds to α1A-, α1B-, α1D-, α2A-, α2B-, and α2C-ARs in a radioligand binding assay (IC50s = 0.08, 0.56, 0.45, 0.98, 1.8, and 0.22 μM, respectively); increases intracellular calcium levels in HEK293 cells transfected with human α2B-ARs (EC50 = 99 μM) but not other α-ARs; a 5-HT1 receptor agonist (Kis = 0.7 and 14 nM for the human 5-HT1D and 5-HT1B receptors, respectively); inhibits forskolin-induced cAMP production in CHO Pro 5 cells expressing human 5-HT1D and 5-HT1B receptors by 62 and 49%, respectively, at 1 μM; induces contraction of isolated dog nasal mucosal blood vessels at 0.25 μg/ml; reduces nasal patency in dogs when administered topically or intravenously

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