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Apexbio Technology LLC Y-27632 146986-50-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B12935.1
Y-27632 (CAS 146986-50-7) is a selective inhibitor of Rho-associated protein kinases (ROCK) specifically targeting ROCK1 and ROCK2 isoforms It competitively binds to the ATP-binding site inhibiting ROCK1 and ROCK2 with Ki values of 0 22 M and 0 30 M respectively Compared to other kinases such as citron kinase PKN and PKC Y-27632 exhibits significantly higher selectivity toward ROCK isoforms In cellular assays Y-27632 at 10 M concentration effectively disrupts stress fiber formation in Swiss 3T3 fibroblast cells It is widely used in cell biology research to study ROCK signaling pathways and cytoskeletal dynamics
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