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Apexbio Technology LLC Y-39983 dihydrochloride 173897-44-4 5mg
Supplier: Apexbio Technology LLC B11765
Y-39983 dihydrochloride (CAS 173897-44-4) is a selective inhibitor of Rho-associated coiled-coil containing protein kinase (ROCK) exhibiting an IC50 of 3 6 nM for ROCK inhibition It demonstrates substantially reduced inhibitory activity against protein kinase C (PKC IC50 0 42 M) and Ca2 /calmodulin-dependent protein kinase II (CaMKII IC50 0 81 M) In ex vivo studies Y-39983 dihydrochloride induces relaxation of pre-contracted rabbit ciliary arteries and has been shown to increase optic nerve head blood flow Furthermore dose-dependent reductions in intraocular pressure have been observed in both rabbit and monkey models These properties suggest its value for research on ROCK-related signaling in ocular physiology and vascular tone regulation
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