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STEMCELL Technologies Verteporfin, Size: 5 mg
Supplier: STEMCELL Technologies 1000262
Verteporfin is a benzoporphyrin derivative that inhibits autophagosome formation by directly targeting and modifying p62, a scaffold protein that targets polyubiquitinated proteins for degradation (Donohue et al.). Verteporfin also disrupts YAP-TEAD interactions by enhancing trypsin cleavage of YAP (EC₅₀ = 100 nM; Brodowska et al.; Liu-Chittenden et al.).CANCER RESEARCH· Inhibits the growth, proliferation, and viability of human retinoblastoma cells (Brodowska et al.).· Inhibits self-renewal in cancer stem cells with high YAP1 and ALDH1 levels (Song et al.).
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