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Medchemexpress LLC YB-0158 (Wnt pathway inhibitor 2) | 1144043-83-3 | 99.8% | 703.59 | 50 MG
Supplier: Medchemexpress LLC HY13654150MG
YB-0158 is a reverse-turn peptidomimetic that acts as a potent colorectal cancer stem cell (CSC) targeting agent. It disrupts Sam68-Src interactions and induces apoptosis in CRC cells, demonstrating anti-cancer activities.
- Significantly increases apoptosis in CRC cells
- Decreases CBP recruitment at the promoter of Wnt/beta-Catenin target genes LGR5 and MYC
- Shows an EC50 of 1.64 μM in cultured MC38 cells
- Soluble in DMSO (100 mg/mL)
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