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Apexbio Technology LLC YH239-EE 1364488-67-4 10mg
Supplier: Apexbio Technology LLC B475610
YH239-EE (CAS 1364488-67-4) is a small molecule antagonist of the p53-MDM2 interaction By disrupting the binding between p53 a tumor suppressor transcription factor and its negative regulator MDM2 YH239-EE reactivates p53 signaling pathways In acute myeloid leukemia (AML) cell models such as OCI-AML-3 MOLM-13 and NB4 YH239-EE inhibits cell proliferation and induces cell cycle arrest accompanied by significant accumulation of sub-G1 populations It promotes apoptosis with rates observed up to 13 1-fold over control in NB4 cells and activates caspase 3/7 in MOLM-13 cells Enantiomers display distinct biological activity with EC50 values of 7 5 M and 25 2 M YH239-EE serves as a valuable tool for studying p53-MDM2 modulation in cancer research
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