Medchemexpress LLC Yk-2168 | 2571068-74-9 | 98.1% | 315.80 | 1 ML

Supplier:  Medchemexpress LLC HY16291910MM/1ML

YK-2168 is a potent and selective CDK9 inhibitor (IC50 of 5.9 nM) that targets the pS2-RNA Pol II C-terminal domain. It induces apoptosis, suppresses CDK9-regulated genes like MYC and Mcl1, and inhibits tumor growth in CDX mice models. This compound is suitable for cancer research, particularly leukemia.

• Potent and selective CDK9 inhibitor (IC50 of 5.9 nM).
• Induces apoptosis and suppresses CDK9-regulated genes.
• Inhibits tumor growth in CDX mice models (80% inhibition at 10 mg/kg).
• Highly selective over CDK1 and CDK2, with no hERG channel inhibition up to 30 μM.
• Reduces pS2-RNA Pol II CTD levels and upregulates cleaved caspase 3.
• Demonstrates good safety in vivo with no significant body weight changes.

Catalog No. 50-003-92088