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Medchemexpress LLC YK-3-237 | 1215281-19-8 | 99.5% | 372.18 | 5 MG
Supplier: Medchemexpress LLC HY196345MG
YK-3-237 is a SIRT1 activator that targets mutant p53 and inhibits the proliferation of triple-negative breast cancer cells.
- SIRT1 activator
- Targets mutant p53
- Inhibits the proliferation of triple-negative breast cancer cells
- Exhibits anti-proliferative activities toward most breast cancer cell lines tested at submicromolar concentrations
- Preferentially inhibits the proliferation of breast cancer cell lines carrying mtp53
- Deacetylates mtp53 in TNBC cell lines
- Potent activator of Sirt1 on the activation of renal interstitial fibroblasts using NRK-49F cells
- Exposure significantly reduces the expression of α-SMA and fibronectin in a dose-dependent manner
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