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Medchemexpress LLC Yl-939 | 3023925-68-7 | C25H26N6O | 1 ML

Supplier: Medchemexpress LLC HY15209310MM/1ML
YL-939 is a potent ferroptosis inhibitor that targets the PHB2/ferritin/iron axis. It efficiently protects cells from ferroptosis with IC50 values ranging from 0.14 μM to 0.25 μM for various cell lines. It also reduces the level of reactive oxygen species (ROS) in cytosolic and membrane lipids.
- Ameliorates liver damage in an acetaminophen-induced acute liver injury mouse model.
- Inhibits cell death and inflammatory infiltration in liver tissues.
- Improves ferritin protein expression in a concentration-dependent manner.
- Blocks autophagosomes/lysosomes, inhibiting ferritinophagy.
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