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Apexbio Technology LLC YM 022 145084-28-2 10mg
Supplier: Apexbio Technology LLC B672510
YM022 (CAS 145084-28-2) is a potent orally active small molecule antagonist of the gastrin/cholecystokinin-B (CCK-B) receptor exhibiting high selectivity over the CCK-A receptor In binding assays YM022 demonstrates Ki values of 68 pM for CCK-B receptors and 63 nM for CCK-A receptors indicating preferential affinity Preclinical studies indicate that YM022 suppresses gastrin-stimulated gastric acid secretion and inhibits activation of histidine decarboxylase Due to its defined receptor selectivity and modulatory effects on gastrointestinal physiology YM022 is widely employed in research investigating gastrointestinal disorders and related regulatory pathways
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