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Apexbio Technology LLC YM-155 hydrochloride 355406-09-6 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A39475.1
YM-155 hydrochloride (CAS 355406-09-6) is a small molecule inhibitor that selectively targets survivin the smallest member of the inhibitor of apoptosis (IAP) protein family Unlike broader IAP inhibitors YM-155 preferentially reduces survivin expression without significantly affecting related family proteins or BCL-2 proteins Treatment with YM-155 has demonstrated antiproliferative activity across diverse human tumor cell lines and induced tumor regression in preclinical xenograft models of non-small cell lung cancer (NSCLC) melanoma bladder cancer aggressive non-Hodgkin lymphoma and breast cancer Additionally YM-155 reduced metastatic potential and prolonged survival in animal models bearing triple-negative breast cancer xenografts highlighting its utility in cancer research
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