Medchemexpress LLC YM-244769 | 838819-70-8 | 99.2% | 443.47 | 50 MG

Supplier:  Medchemexpress LLC HY136182A50MG

YM-244769 is a potent, selective, and orally active Na+/Ca2+ exchanger (NCX) inhibitor. It preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode) with IC50s of 18 nM and 50 nM, respectively. It efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage and can increase urine volume and urinary excretion of electrolytes in mice.

• Potent, selective, and orally active Na+/Ca2+ exchanger (NCX) inhibitor.
• Preferentially inhibits NCX3 (IC50 = 18 nM).
• Suppresses unidirectional outward NCX current (Ca2+ entry mode) with an IC50 of 50 nM.
• Efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage.
• Increases urine volume and urinary excretion of electrolytes in mice.

Catalog No. 50-003-48181