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Medchemexpress LLC YM-244769 dihydrochloride | 1780390-65-9 | 516.39 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY136182A100MG

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YM-244769 dihydrochloride is a potent, selective, and orally active Na+/Ca2+ exchanger (NCX) inhibitor. It preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode). This compound efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage.

  • Potent, selective, and orally active Na+/Ca2+ exchanger (NCX) inhibitor
  • Preferentially inhibits NCX3
  • Suppresses unidirectional outward NCX current (Ca2+ entry mode) with IC50s of 18 nM and 50 nM
  • Efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage
  • Increases urine volume and urinary excretion of electrolytes in mice

Catalog No. 50-003-50837


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