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Medchemexpress LLC Ym-244769 dihydrochloride | 1780390-65-9 | 516.39 | 25 MG
Supplier: Medchemexpress LLC 25MGHY136182
Ym-244769 dihydrochloride is a potent, selective, and orally active Na+/Ca2+ exchanger (NCX) inhibitor. It preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode), with IC50 values of 18 nM and 50 nM, respectively. This compound efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. It can also increase urine volume and urinary excretion of electrolytes in mice.
- Potent and selective Na+/Ca2+ exchanger (NCX) inhibitor.
- Preferentially inhibits NCX3.
- Suppresses unidirectional outward NCX current (Ca2+ entry mode).
- Protects against hypoxia/reoxygenation-induced neuronal cell damage.
- Increases urine volume and urinary excretion of electrolytes.
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