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Medchemexpress LLC YM-244769 dihydrochloride | 1780390-65-9 | 516.39 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY13618250MG

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YM-244769 dihydrochloride is a potent, selective, and orally active Na+/Ca2+ exchanger (NCX) inhibitor. It preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode). This compound efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage and increases urine volume and urinary excretion of electrolytes in mice.

  • Potent and selective Na+/Ca2+ exchanger (NCX) inhibitor
  • Preferentially inhibits NCX3 with an IC50 of 18 nM
  • Suppresses unidirectional outward NCX current (Ca2+ entry mode)
  • Protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage
  • Increases urine volume and urinary excretion of electrolytes in mice
  • Also inhibits NCX1 (IC50: 68 nM) and NCX2 (IC50: 96 nM)

Catalog No. 50-003-51556


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