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Medchemexpress LLC YNT-185 dihydrochloride | 1804978-82-2 | 99.8% | 688.66 | 25 MG
Supplier: Medchemexpress LLC 25MGHY136181
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist. It demonstrates high selectivity with EC50s of 0.028 μM for OX2R and 2.75 μM for OX1R. This compound has been shown to ameliorate narcolepsy-cataplexy symptoms in mouse models, increasing wakefulness and decreasing NREM sleep time.
- Selective orexin type-2 receptor (OX2R) agonist
- Nonpeptide compound
- EC50 of 0.028 μM for OX2R
- Ameliorates narcolepsy-cataplexy symptoms in mouse models
- Increases wakefulness
- Decreases NREM sleep time
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