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Medchemexpress LLC YS-49 monohydrate | 3028631-24-2 | C20H22BrNO3 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY15477A10MM/1ML

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YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, reducing RhoA/PTEN activation in 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, exhibiting a strong positive inotropic action through activation of cardiac β-adrenoceptors.

  • Concentration-dependently inhibits the accumulation of nitrite in RAVSMC and RAW 264.7 cells.
  • Suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.
  • Significantly reduces serum NOx levels in LPS-treated rats.

Catalog No. 50-003-76932


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