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Medchemexpress LLC Yuanhuacine (Gnidilatidin) | 60195-70-2 | 1 MG
Supplier: Medchemexpress LLC HYN72251MG
Yuanhuacine (Gnidilatidin), a diterpene from *Daphne genkwa*, is an effective and highly selective inhibitor of the basal-like 2 (BL2) subtype of TNBC. It can induce G2/M cell cycle arrest and exhibits broad anti-tumor activity. Yuanhuacine is an orally active DNA damaging agent.
- Highly selective inhibitor for the BL2 subtype of TNBC.
- Induces G2/M cell cycle arrest.
- Exhibits broad anti-tumor activity.
- Acts as an orally active DNA damaging agent.
- Inhibits proliferation in various cancer cell lines including H1993, H358, H460, Calu-1, H1299, A549, UMUC3, and HCT116.
- Downregulates mTOR activation.
- Inhibits migration of H1993 cells.
- Upregulates p21 transcription and protein expression by regulating Sp1 protein stability.
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