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Apexbio Technology LLC (Z)-4-Hydroxytamoxifen 68047-06-3 5mg
Supplier: Apexbio Technology LLC B54215
(Z)-4-Hydroxytamoxifen is a biologically active metabolite of tamoxifen functioning as a selective estrogen receptor (ER) modulator As a nuclear receptor ER mediates cellular responses through ligand-induced conformational changes and transcriptional modulation Upon ligand binding ER alters gene expression patterns influencing cell proliferation differentiation and growth (Z)-4-Hydroxytamoxifen exhibits higher binding affinity to ER compared to its parent compound tamoxifen preferentially acting as an antagonist It has been widely employed in vitro and in vivo research models to investigate ER-mediated signaling pathways particularly related to hormone-dependent breast cancer proliferation and estrogen-driven physiological responses
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